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KMID : 0861020150300020019
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Korea Journal of Herbology
2015 Volume.30 No. 2 p.19 ~ p.24
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Haeae-tang including Artemisia argyi Folium promotes hair growth in hair-removed C57BL/6 Mice
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Kim Nam-Hee
Moon Sun-Hee
Kim Mi-Ryeo
Lee Young-Sun
Yoo Wang-Keun
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Abstract
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Objectives : The experiment was performed to investigate promotive effects of haeae-tang (HET) extract, a traditional Korean medicinal recipe, on hair growth, protein and gene expression in hair-removed C57BL/6.
Methods : In experiment, animals were divided into 3 groups including normal (vehicle), HET ethanol extract and 5% minoxidil-treated groups (Minoxidil, positive control). The vehicle or testing samples were daily treated with 0.2ml per on hair-shaved dorsal skin of C57BL/6mice for 15 days. Effects of testing samples on hair growth was monitored through phototrichogram analysis by folliscope on the initial, 5th, 10th, 15th day, respectively. Also, gene and protein expressions of vascular endothelial growth factor (VEGF) and Insulin like growth factor-1 (IGF-1), relevant to hair growth, were examined.
Results : Hair density and hair thickness of Minoxidil treated-group was significantly increased compared to that of vehicle application on the 15thday, respectively. Dorsal hair density of HET treated-group was significantly increased compared to that of vehicle application on the 15thday. In addition, the Minoxidil group significantly increased the expression of cutaneous IGF-1 protein and mRNA compared to that of the vehicle-applied group on the 15th day. And HET-treated group significantly increased the expression of dorsal VEGF protein compared to that of the vehicle-applied group on the 15th day.
Conclusions : These results suggest that this Korean medicinal recipe, HET has promoting activity on hair growth in an Alopecia animal model thus it can be used as a material of agent or products for improvement or prevention of alopecia.
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KEYWORD
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Haeae-tang, alopecia model, Hair growth, IGF-1, VEGF
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